While it is often treated as a vegetable, squash is actually a type of fruit, as it comes from a flower and contains seeds. You can enjoy these seeds, as well as the flesh and, in many cases, the skin. The many vitamins, minerals, and antioxidants found in squash provide several health benefits. The antioxidants in squash can play an important role in reducing oxidative stress. In turn, this may help with cancer prevention.